Tris-base 99.99% CAS NO.77-86-1

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Tromethamine, CASNo. 77-86-1, also known as Tris, is a well-known biological buffer. In addition, tromethamine is also used to prepare surfactants, vulcanization accelerators and intermediates of some drugs, and can also be used as pharmaceutical excipients, cosmetic additives, decoration coatings, etc.

Main application areas:

1. Pharmaceutical excipients: tromethamine can be used as an acid-base balance regulator, and the representative drugs are iopromide injection, etc. These drugs are diagnostic drugs, which are used for intravascular and intracavitary, enhanced computed tomography (CT), arteriography and venography, arterial/venous digital subtraction angiography (DSA), intravenous urography, endoscopic retrograde cholangiopancreatography (ERCP), arthrography and other body cavity examinations, but cannot be used in the sheath. Tromethamine is widely used in medicine. Whether as medicine itself, medicine intermediate or medicine auxiliary material, tromethamine plays an important role in the field of medicine, providing an effective way for antibacterial and anti-infection, pain relief, medical diagnosis and life saving.

2. Biological buffer: Tris is commonly used as biological buffer and is usually prepared with pH values of 6.8, 7.4, 8.0 and 8.8. Its structural formula and pH value vary greatly with temperature. In general, the PH decreases by 0.03 for each degree of temperature increase. Tris has been widely used in the preparation of buffer solutions in biochemistry and molecular biology experiments. For example, both TAE and TBE buffers commonly used in biochemical experiments (for the dissolution of nucleic acids) require the use of Tris. It can be condensed with aldehydes because it contains amino groups. Tris is a weak base with a pKa of 8.1 at room temperature (25 C; According to buffer theory, the effective buffer range for Tris buffer is pH7.0 to 9.2. The pH of the aqueous solution of Tris base is about 10.5, and hydrochloric acid is generally added to adjust the pH to the required value to obtain the buffer solution with the pH value. However, the effect of temperature on the pKa of Tris should be noticed at the same time. Since Tris buffer is a weakly basic solution, DNA is deprotonated in such a solution, improving its solubility. People often add EDTA into Tris hydrochloric acid buffer to prepare "TE buffer", and TE buffer is used for DNA stabilization and storage. If the pH-adjusted acid solution is replaced with acetic acid, then "TAE Buffer" (Tris/Acetate/EDTA) is obtained, and with boric acid, then "TBE Buffer" (Tris/Borate/EDTA) is obtained. These two buffer are commonly used in nucleic acid electrophoresis experiment. TAE, TBE and others prepared by Tris are the most commonly used reagents for DNA electrophoresis, and TE(pH8.0) is mainly used to dissolve DNA. (TE is the combined name of Tris and EDTA. ) 1MTris-HCl6.8 and 1.5MTris-HCl8.8 are the most commonly used reagents for SDS-PAGE. Tromethamine (CASNo. 77-86-1), also known as Tris (hydroxymethyl) aminomethane, is a well-known biological buffer. In addition, tromethamine is also used for preparing surfactants, vulcanization accelerators and intermediates of some medicines, and can be used as medicinal auxiliary materials, cosmetic additives, decoration coatings and the like.

3. Pharmaceutical intermediates: As organic amine, tromethamine can form water-soluble double salts with insoluble drugs with acidic groups. Representative drugs include dexketoprofen tromethamine, fosfomycin tromethamine, the intermediate of carboprost tromethamine, and ketorolac tromethamine.

4. Cosmetics: tromethamine is also a mild and safe cosmetic additive. As a cosmetic additive, tromethamine is commonly used in some high-end cosmetics, covering Japan, South Korea and Europe and the United States series. For example, the Lan Zhi Reservoir series, the Snow Blossom Show (Snow Blossom Show) and Night Rejuvenation Mask and SKII Fairy Water, which are reputed as "holy products for replenishing water", as well as the Charm Poem Gold Double Essence Dew and Clinique Water Magnetic Field Cream, etc. It is worth mentioning that tromethamine is also used in maternal and infant products, such as the popular Multi-effect Moisturizing Cream for Early Infants.

5, decoration coating: preparing a water-soluble polymer containing Tris structural units as a coating dispersant; Indoor formaldehyde adsorption material preparation, etc.