Dithiothreitol 99% CAS NO.27565-41-9

 DithiothreitolCAS：27565-41-9, also known as Tris, is a well-known biological buffer. In addition, Dithiothreitol is also used to prepare surfactants, vulcanization accelerators and intermediates of some drugs, and can also be used as pharmaceutical excipients, cosmetic additives, decoration coatings, etc.

Main application areas:

One of the uses of DTT is as a reductant and deprotector of thiolated DNA. Sulfur atoms at the end of thiolated DNA tend to form dimers in solution, especially in the presence of oxygen. This dimerization greatly reduces the efficiency of some coupling reaction experiments (such as DNA fixation in biosensors); The addition of DTT in the DNA solution can reduce the DNA dimerization by removing it after a period of reaction.

DTT is also often used for the reduction of disulfide bonds in proteins, which can be used to prevent the formation of protein intramolecular or intermolecular disulfide bonds between cysteine in proteins. However, DTT is often unable to reduce the disulfide bonds embedded in the protein structure (inaccessible to solvents). The reduction of such disulfide bonds often requires protein denaturation (high temperature heating or adding denaturants, such as 6M guanidine hydrochloride, 8M urea or 1% SDS). On the contrary, according to the different reduction rates of disulfide bonds in the presence of DTT, the depth of its embedment can be determined.

Xuzhou Maikai Biotechnology Co., Ltd. was established in November 2021 with a registered capital of 15 million yuan. It is an emerging R&D enterprise based on anti-tumor drugs and biotechnology. The company cooperates with Dalian University of Technology, Zhejiang University, Jinan University, etc. Colleges and universities have good cooperative relations. The founders and shareholders of the company have 20 years of working experience in the chemical industry. They have in-depth understanding and control of the product market. The technology is mature and advanced, and the product quality has reached the pharmaceutical level, which has been fully recognized by customers in the industry.

The company focuses on the biochemical industry, aspires to become the world's leading brand in this industry, and contributes to the cause of human health. Since its establishment, the company has always adhered to and adhered to the core business philosophy of "morality-based, honesty-first", and regards providing value to customers as our responsibility, which has won praise from customers.

Pharmaceutical Division

We are mainly responsible for the R&D, production and sales of pharmaceutical intermediates and APIs. The products are used in the fields of bio-buffering agents, anti-tumor drugs, cardiovascular and cerebrovascular diseases, steroid drugs, etc.

Electronic New Materials Division

We are mainly engaged in the research and development of additives for the battery industry, such as fluorinated ethylene carbonate (FEC), chlorinated ethylene carbonate (CEC), etc. We deliver high quality and high specification products to the battery industry at home and abroad.

Custom Synthesis Division

We mainly undertake the development of products commissioned by domestic and foreign pharmaceutical companies and CDMO companies. The company has strong technical research on special types of reactions such as coupling, chlorination, diazotization, hydrogenation, and ammoniation. We are also currently working on product process improvement using continuous flow equipment to obtain faster and safer reaction conditions.

Pesticide Division

We are mainly responsible for the research and development, production and sales of intermediates and original drugs for plant growth regulator products.