Hyodeoxycholic acid CAS NO.83-49-8

Porcine deoxycholic acid (HDCA) has the effects of lowering blood lipids, antispasmodic and expectorant. It is clinically used to treat hyperlipidemia, atherosclerosis, tracheitis, viral upper respiratory tract inflammation in children, and indigestion caused by hepatobiliary diseases; It has certain inhibitory effect on pertussis, diphtheria and staphylococcus aureus; As an effective ingredient in Qingkailing injection, it has good effect on the treatment of acute leukemia through clinical observation. In vitro experiments have proved that HDCA has the effect of inducing cell apoptosis and inhibiting cell proliferation and division. Chemical properties This product is a kind of bile acid extracted from pig bile. It is white or slightly yellow powder, smelly, slightly fishy and bitter. Mp197 ℃ (decomposition). Slightly soluble in alcohol, slightly soluble in acetone, very slightly soluble in ether and chloroform, almost insoluble in water. This product can inhibit the formation of cholic acid and dissolve fat, and reduce cholesterol and triglyceride in blood. Purpose Porcine deoxycholic acid is applicable to type Ia and Ib hyperlipidemia and atherosclerosis. It has certain antibacterial effect on pertussis bacillus, diphtheria bacillus, staphylococcus aureus, etc. It is also applicable to cholangitis, cholecystitis, cholelithiasis and other non-obstructive cholestasis. It can accelerate the excretion of gallbladder contrast agent from the liver to help develop. It can promote intestinal fat decomposition and absorption of fat-soluble vitamins, and can be used for indigestion caused by liver and gallbladder diseases. It can be used as an anti-inflammatory drug to treat chronic bronchitis and viral respiratory inflammation in children. Occasionally, it may cause gastrointestinal discomfort and mild diarrhea. Purpose: One of the raw materials for the treatment of gallstones; Raw materials for synthesis of ursodeoxycholic acid (UDCA) and other steroid compounds; The main raw materials for the production of artificial bezoar are used to lower blood lipids, lower blood cholesterol, and lower transaminase chemicalbook. Purpose: Deoxycholic acid can reduce blood cholesterol, treat and prevent coronary heart disease, hypertension, etc. The production method uses fresh pig bile as raw material to prepare pig bile acid. Take fresh pig bile, add the supernatant of saturated limewater and heat it to boiling to prepare calcium bilirubin salt. The mother liquor is acidified with hydrochloric acid while it is hot until Congo red turns blue, precipitate the black colloidal precipitate combined with pig bile acid, remove the emulsion, collect the precipitate, and wash it with tap water to become hard and brittle to obtain pig bile acid. Pig bile [saturated limewater] → [pH11-12100 ℃] mother liquor [HCl] → precipitate [water] → preparation of crude pig bile acid Take crude pig bile acid, add 1.5 times the mass of sodium hydroxide, add 9 times the volume of water, heat for more than 16 hours, cool, stand and layer, pour out the upper layer of light yellow liquid, dissolve the precipitate with a small amount of water, add dilute hydrochloric acid or sulfuric acid (2:1) to acidize until the Congo red test paper turns blue, take out the precipitate, filter, and wash to neutral, It is golden yellow and vacuum dried to obtain the crude product. Swine bile acid [NaOH, water] → [>16h] saponification solution [HCl] → preparation of crude product of isodeoxycholic acid. Take the crude product, add 5 times the amount of ethyl acetate, add 150-200g/L activated carbon, heat, stir, reflow, dissolve, cool, filter, filter the residue, add 3 times the amount of ethyl acetate to reflow, filter, combine twice the filtrate, add 200g/L anhydrous sodium sulfate, filter, and get the filtrate. Concentrate to 1/5-1/3 of the original volume, cool, precipitate crystals, filter, obtain crystals, wash with ethyl acetate, and vacuum dry to obtain the finished product of isodeoxycholic acid. Crude product [ethyl acetate, activated carbon] → filtrate [anhydrous Na2SO4] → filtrate → crystal [ethyl acetate] → finished product of isodeoxycholic acid.

Xuzhou Maikai Biotechnology Co., Ltd. was established in November 2021 with a registered capital of 15 million yuan. It is an emerging R&D enterprise based on anti-tumor drugs and biotechnology. The company cooperates with Dalian University of Technology, Zhejiang University, Jinan University, etc. Colleges and universities have good cooperative relations. The founders and shareholders of the company have 20 years of working experience in the chemical industry. They have in-depth understanding and control of the product market. The technology is mature and advanced, and the product quality has reached the pharmaceutical level, which has been fully recognized by customers in the industry.

The company focuses on the biochemical industry, aspires to become the world's leading brand in this industry, and contributes to the cause of human health. Since its establishment, the company has always adhered to and adhered to the core business philosophy of "morality-based, honesty-first", and regards providing value to customers as our responsibility, which has won praise from customers.